Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation
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چکیده
منابع مشابه
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.
Snail1 is a central regulator of epithelial cell adhesion and movement in epithelial-to-mesenchymal transitions (EMTs) during embryo development; a process reactivated during cancer metastasis. While induction of Snail1 transcription precedes EMT induction, post-translational regulation of Snail1 is also critical for determining Snail1's protein level, subcellular localization, and capacity to ...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2011
ISSN: 0261-4189
DOI: 10.1038/emboj.2011.357